So today I tried to do a multitrack recording with Nuendo 6 on OSX with the SQ-5.
After setting up the device configuration in Nuendo nothings happens. Audio doesnt play and also recording is not possible.
But playing from iTunes was working, and the Sound settings showed audio input too.
After trying some settings and troubleshooting I found a solution: I created an aggregated device, with just the SQ-5 in it.
When I chose the aggregated device in Nuendo, it worked like a charm.
Sorry for the late reply, not always on this forum
As it says in my post. I solved the issue by creating an aggregated device in osx.
I did not do a lot of DAW lately, but it works as an input output device. I did not try to use the faders yet (as daw remote), but it would be done easily with a midi layer in Nuendo.