We have an SQ7 (not a QU) and I have just configured our ME-1s to use global direct outs for the bulk of the musicians and vocalist channels so they are in charge of their mix.
However, I did the same for the leader and preacher microphones and (of course) that causes problems for the Worship band!
We group our preacher and leader microphones into a ‘group’ and I have sent this group output to the ME-1. This group output obeys the mutes, and solved all of my problems.
See if this is also applicable on the QU.
EDIT: I have just found the manual for the QU5 and it is the same as our SQ7. The feed to the ME-1 is on the exit of the output patch, so you can patch any direct out, aux, group or matrix to any ME-1 channel.